EMERGENCY has experience building and operating health facilities in the midst of epidemics. When COVID hit, the organization implemented several actions to inform communities, prevent contagion and care for the most vulnerable. Our response approach focused on health systems and beyond, ensuring flexibility and tailored replicability with the capacity to involve and coordinate with multiple stakeholders, ranging from international actors to local partners. Beneficiaries include over 300,000 patients worldwide, more than 16,000 vulnerable individuals, and public institutions. Our facilities remained open and we contributed to building resilient communities through information and awareness-raising. In the future, this model can be scaled up to support other actors. EMERGENCY’s approach has the potential to fulfil the right to health, even when confronted with unprecedented challenges.