The Global Commission on Drug Policy was established by political leaders, cultural figures, and globally influential personalities to promote evidenced-based drug policy reforms that also address issues of public health, social integration and security, with a strict regard for human rights. The Commission currently comprises 26 members, including 14 former Heads of States or Government and three Nobel Prize laureates. Since its founding in 2011, the Global Commission has fundamentally changed the global debate on drug policy and public awareness of the issue. Its thematic reports have generated reactions from the White House and other government and close to 10,000 media articles in the world’s top media in over 180 countries. They have been used to justify government and legislative reforms, including in Brazil, Colombia, Mexico and Uruguay. The members of the Global Commission have met and discussed with the UN Secretary General and heads of UN agencies, e.g. UNODC, UNDP, WHO, and UNAIDS, as well as national governments. They have supported the creation of coalitions of “like-minded” states and strengthened civil society groups around the world to advocate for progressive reform.